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Diptoindonesin G

CAS No. 1190948-58-3

Diptoindonesin G ( Dip G )

Catalog No. M10656 CAS No. 1190948-58-3

A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Diptoindonesin G
  • Note
    Research use only, not for human use.
  • Brief Description
    A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells.
  • Description
    A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.
  • Synonyms
    Dip G
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1190948-58-3
  • Formula Weight
    360.32
  • Molecular Formula
    C21H12O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2=C3C(OC(C4=CC=C(O)C=C4)=C3C5=C1C(O)=CC(O)=C5)=CC(O)=C2
  • Chemical Name
    4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhao Z, et al. Chem Biol. 2015 Dec 17;22(12):1608-21.
2. Juliawaty LD, et al. Nat Prod Commun. 2009 Jul; 4(7):947-50.
3. Gao J, et al. Cell Death Dis. 2017 May 4;8(5):e2765.
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